The best month to fly between Amsterdam and Istanbul is March and the most expensive month to fly is July. (Average prices, based on 1775 datapoints.)
The best day to arrive at Amsterdam is Wednesday and it would be best to avoid Friday, as prices are on average 70.48% higher than on Wednesday. (Average prices, based on 1906 datapoints.)
The best time to fly is at around 7. (Average prices, based on 2200 datapoints.)