Flight Arturo Merino Benitez International Airport departs from Santiago Arturo Merino Benitez International Airport at 21:45 and arrives at Houston George Bush Intercontinental Airport at 05:20.
The flighttime is about 9h 35m. The distance travelled ("as the bird flies"): 2458 Km. So the average speed is roughly 256 Km.
There is an 2 hour time difference between Santiago and Houston