Flight Guarulhos International Airport departs from Sao Paulo Guarulhos International Airport at 14:20 and arrives at Madrid Adolfo Suárez Madrid–Barajas Airport at 05:45.
The flighttime is about 10h 25m. The distance travelled ("as the bird flies"): 7748 Km. So the average speed is roughly 744 Km.
There is an 5 hour time difference between Sao Paulo and Madrid