Below you can find the flight schedule for Madrid to Rome for May. If you are looking for flight fares, please check the cheap flights Madrid to Rome, or you can use the search form at the top.
| Airline | Flight number | Departure | Arrival | Flight time |
| Air Europa | UX1043 | 07:00 | 09:30 | 2h 30m |
| Air Europa | UX1045 | 13:20 | 15:50 | 2h 30m |
| Air Europa | UX1047 | 14:55 | 17:25 | 2h 30m |
| Alitalia | AZ59 | 05:50 | 08:15 | 2h 25m |
| Alitalia | AZ61 | 11:20 | 13:50 | 2h 30m |
| Alitalia | AZ63 | 17:30 | 19:55 | 2h 25m |
| Alitalia | AZ3119 | 18:00 | 20:25 | 2h 25m |
| Alitalia Cityliner | CT61 | 12:10 | 14:30 | 2h 20m |
| Iberia Airlines | IB3230 | 08:40 | 11:10 | 2h 30m |
| Iberia Airlines | IB3232 | 11:20 | 13:50 | 2h 30m |
| Iberia Airlines | IB3326 | 13:00 | 15:25 | 2h 25m |
| Iberia Airlines | IB3236 | 15:30 | 18:05 | 2h 35m |
| Iberia Airlines | IB3234 | 17:00 | 19:30 | 2h 30m |
| Iberia Airlines | IB3238 | 21:15 | 23:45 | 2h 30m |
| Ryanair | FR9674 | 06:00 | 08:15 | 2h 15m |
| Ryanair | FR9686 | 20:30 | 22:55 | 2h 25m |
| Wizz Air | W68334 | 19:25 | 22:00 | 2h 35m |
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